Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein
نویسندگان
چکیده
منابع مشابه
A Novel mAb against a Human CD34 Peptide Reacts with the Native Protein on CD34+ Cells
Background: Human CD34 is a transmembrane glycoprotein which is expressed in human hematopoietic stem cells (HSCs) and the small- vessel endothelial cells of a variety of tissues. CD34 plays a critical role as a marker for diagnosis and classification of leukemia. Anti CD34 antibodies are used for isolation and purification of HSCs from bone marrow, peripheral blood and cord blood. Objective: ...
متن کاملAdult human circulating CD34⁻Lin⁻CD45⁻CD133⁻ cells can differentiate into hematopoietic and endothelial cells.
A precise identification of adult human hemangioblast is still lacking. To identify circulating precursors having the developmental potential of the hemangioblast, we established a new ex vivo long-term culture model supporting the differentiation of both hematopoietic and endothelial cell lineages. We identified from peripheral blood a population lacking the expression of CD34, lineage markers...
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TLR9 recognizes DNA sequences containing hypomethylated CpG motifs and is a component of the innate immune system highly conserved during eukaryotic evolution. Previous reports suggested that the expression of TLR9 is restricted to plasmacytoid dendritic cells and B lymphocytes. Our results indicate that low levels of TLR9 are present on the cell surface of freshly isolated human monocytes, and...
متن کاملHEMATOPOIESIS AND STEM CELLS Adult human circulating CD34 Lin CD45 CD133 cells can differentiate into hematopoietic and endothelial cells
1Department of Transfusion Medicine, Laboratory of Stem Cells, Spirito Santo Hospital, Pescara, Italy; 2Laboratory of Clinical and Experimental Immunology, Department of Translational Medicine, University of Milan and IRCCS Istituto Clinico Humanitas, Rozzano, Milano, Italy; 3Center for Cancer Research, National Cancer Institute, Laboratory of Cellular Oncology, National Institutes of Health (N...
متن کاملHuman Trophoblast Progenitor Cells Express and Release Angiogenic Factors
Trophoblast stem cells develop from polar trophoectoderm and give rise to the cells that generate the placenta. Trophoblast cells are responsible for the uterinal invasion and vascular remodeling during the implantation of the embryo. However this knowledge is not yet to be confirmed for trophoblast progenitor cells (TPCs). In this study, we aimed to demonstrate that human TPCs (hTPCs) express ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0306431101